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Comparable turnover rates (t1/2=6.4) on the membrane were recently also reported for the haematopoietic Nap1 isoform Hem-1 (Weiner et al, 2007).
This mutant has a comparable turnover to the wild-type kinase and therefore can be used to meaningfully test the effect of changing primary specificity on phosphoregulatory networks in vivo.
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Comparable turnover among senior managers can affect WISN implementation because of the loss of institutional memory and the disruption to functioning teams [ 36].
Comparable to turnover of Baf250a protein, Tbx3 protein began to decrease at 12 h after tamoxifen induction.
The biological effects were evident only in EOC cell lines and not in the non-tumoural ovarian I64-hTERT cell line in spite of the comparable cellular turnover of the two cellular models (Iorio et al, 2005 and present results).
This was an exploratory study, and no reliable comparable bone-turnover-marker data are available in this study population.
Alternatively, physically adding two linear processes with time constants (1/rate constants) comparable to protein turnover time would tend to make four lifetimes more similar on the scale of protein turnover time without changing the net cooperativity.
Striking species differences were seen as mouse CYP1B1 did not activate Phe at all, but human CYP1B1 exhibited a significant metabolic turnover comparable to CYP1A1 and CYP1A2.
Furthermore, the shrinkage of microtubules again visualized with MBD-VVCA coincided with abrupt depolymerization or dissipation of actin filaments at microtubule tips (Figure S4; Movie S8), indicating that actin filaments on microtubules undergo rapid turnover, comparable to other Arp2/3 complex-dependent structures such as the lamellipodium [7].
Consequently, isolated catalytic domains should show catalytic turnover comparable to that of activated sGC.
Here, we found that HEGs undergo a fast gain-and-loss turnover comparable with introns in the yeast mitochondrial 21S-rRNA gene, which is unexpected, as the intron and HEG are generally believed to move together as a unit.
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