Typically for a drug that does not show any colonic absorption, the plasma profile will decline after reaching Cmax in a more or less exponential way comparable in shape to an iv injection as can be seen on Fig. 8 for diltiazem iv.
The target weight for a tablet PC, Clark says, is about 3 pounds, and it should be comparable in size and shape to a pad of standard-sized notebook paper.
Seeds created by sonication, which were comparable in shape and size to the globular species in the pathway, were observed to grow through multidirectional elongation into fibers, suggesting a mechanism for growth of globular species into fibers.
Using the alternative approach with a smooth function to model time-varying associations produced estimates that are comparable in shape [see Supplemental Material, Figure 4 (http://www.ehponline.org/members/2008/11711/suppl.pdf)].
By rolling these sheets, they created tubular structures comparable in size to a single bull sperm.
The results reveal that porcine MCL is comparable in both shape and size to human MCL and exhibits similar structural and material failure properties, thus making it a feasible model.
This work suggests that such constrained cyclic peptides can be used as scaffolds to create a range of novel protein-like supramolecular structures (e.g. cylinders, troughs, cones, multi-loop structures, helix bundles) that are comparable in size, shape and composition to bioactive surfaces of proteins.
He cited Bristol-Myers Squibb, a company comparable in size to Schering with an attractive product pipeline.
Pre-experimental calibration ensured comparable performance in shape and color tasks for the fMRI experiment (see Materials and methods).
T-quantile normalization reduces the variability between the data distributions of individual microarrays, resulting in ROC curves that are more comparable in both shape and AUC.
