In the OPTIMOX1 trial, ORR 59%, median PFS 9.0 months, and median OS 20.7 months were comparable in old-elderly patients [ 19].
Early health-related quality of life perception after surgery resulted comparable in older and younger patients.
Furthermore, the efficacy and adverse event profile of duloxetine appears to be comparable in older (age ≥ 65) and younger patients (age 18 64).
The results reported here demonstrate that the efficacy profile of sunitinib appears comparable in older and younger patients with advanced RCC, with some limited differences in the safety profiles.
Another study showed that the level of depression was comparable in older (≥65 years) and younger (45 – 65 years) cancer patients 3 months, 15 months, and 8 years after cancer diagnosis [ 28].
The beneficial effect of stress protein up-regulation in cardiovascular tissue has been widely documented (38), as well as the failure to induce the HSR to a comparable extent in old and young animals (11).
Levels of infection differed significantly between the two villages in the two younger age groups (ages 2 20years old) but were comparable in the oldest age group (21 years and above).
Comparable experiments in older people have yet to be done, though.
In summary, we find that geriatric syndromes, diabetes complications, and hypoglycemia are associated with lower HRQL to a comparable degree in older adults with diabetes.
Indeed, a comparable study in older people with MCI has suggested that aerobic fitness may be the most important physical performance, besides strength, balance, and mobility, that is related to the volume of the hippocampus [ 61]; this has been confirmed in another study in people with (very) mild AD [ 62].
