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Indeed, a study by the BrainNet Europe Consortium has demonstrated that the quality of silver stainings varies considerably even in the same laboratory, which makes reproducibility and comparability of this method very difficult [ 56, 57].
Initial publications by Volkov and Coppens were very encouraging regarding the comparability of this method with theoretical estimates of the interaction energy, and we were interested to use this approach to determine the relative lattice energies of the polymorphs of sulfathiazole from the charge density analysis.
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Further research based on simulation studies is required to provide better insights into the comparability of the methods in terms of statistical power for designing CRTs.
A complete set of AUC and AUC50 statistics is given in Additional file 1. Detailed examination of the individual AUC50 results, which give the performance of the methods at high specificity, shows the comparability of the methods.
In most instances, the comparability of these methods has not been established, although analytical techniques using high-performance liquid chromatography interfaced with tandem mass spectrometry provide the most reliable data.
Clear gaps in current literature are cross-sectional, multi-country, collaborative studies ensuring comparability of methods; this could potentially be a great step forward in this field of inquiry.
To assess the comparability of the developed method with existing methods, we performed regression and Bland Altman analysis on the 25-OH D concentration of 12 DEQAS samples as measured by laboratories registered with DEQAS using LC-MS (Fig. 5a).
#In order to ensure the comparability of our method and the method based on correlation of gene expression and drug activity, we kept the number of drug-CRGs obtained by both methods equal with each other.
In order to ensure the comparability of our method and the method based on gene expression, we keep number of predicted drug-CRG pairs obtained by both methods equal with each other.
In order to ensure comparability of method results, their scores are converted to probabilities as probability values are comparable and combinable with each other.
The comparability of the new method was examined with an automated analyzer.
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