Sentence examples for compaction activity from inspiring English sources

This model provides a straightforward explanation for the compaction activity of SMC.

Taken together, these data indicate that the Mrg-binding motif of Cap-H2 is required for Cap-H2 axial compaction activity.

In addition to its chromosome compaction activity, condensin II also has been shown to be a potent antagonist of homologous chromosome pairing in somatic cells and in male meiosis (Hartl et al. 2008a, b; Bateman et al. 2012; Bauer et al. 2012; Joyce et al. 2012).

It has been proposed that the axial compaction activity provided by condensin II is sufficient for its antipairing activity by sequestering sequences into interchromosomal globules and thus indirectly antagonizing trans-interactions between homologs and heterologous chromosomes (Hartl et al. 2008a; Bauer et al. 2012).

However, MsDps1, despite having a DNA binding ability in its dodecameric form, has not been associated with DNA-compaction activity so far.

The small size of the EC compartment, the peculiar chromatin organization and the availability of genome wide gene expression data turn these cells into unique models to study the correlations between chromatin compaction, transcriptional activity and histone modifications.

Our results link condensin-mediated chromosome compaction, an activity connected to mitotic chromosome condensation, to chromosome-wide repression of gene expression in interphase.

Different parts of the genome carry different histone modifications, which in turn determine the level of compaction and transcriptional activity of different regions of the genome.

Nevertheless, our results clearly show that interaction of Cap-H2 with Mrg15 via the Mrg-binding motif is required for condensin II chromosome compaction and unpairing activity.

It will be of interest to reveal genome-wide condensin localization patterns and how these relate to local functions such as interphase chromatin compaction and gene activity, propensity for transvection, RNA trans-splicing, and general chromatin states.

These findings support a model in which Mrg15 acts as a loading factor for Cap-H2 to recruit condensin II to transcriptionally active chromatin to facilitate its compaction and unpairing activities.