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Objective To evaluate the prognostic utility of serum COMP level measured with a new sandwich ELISA, by correlating COMP level with outcome measures of osteoarthritis (OA) progression.
To evaluate the prognostic utility of serum COMP level measured with a new sandwich ELISA, by correlating COMP level with outcome measures of osteoarthritis (OA) progression.Patients (N=48) had symptomatic primary knee OA of Kellgren-Lawrence (K-L) grade I-III and met ACR criteria.
These results were further validated in the GOGO subsets without radiographic OA, in which hypermobility was also associated with a significantly reduced mean serum COMP level (P < 0.0001 adjusted for age).
This may be why we did not find the COMP level to statistically significantly change over time in the adults, although there were enough changes to correlate with SF-36 PCS scores.
Serum COMP levels were measured by sandwich ELISA with monoclonal antibodies 16-F12 and 17-C10 at baseline and at study end and levels were correlated with changes in (1) joint space width (JSW), (2) K-L grade, (3) Lequesne, and (4) WOMAC indices, over 3 years.The change in JSW over 3 years, summed for both knees, correlated positively with serum COMP level at baseline as well as at study end.
There's no sense talking about extras like your relo package if your basic comp level is going to make the guy's head explode.
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The higher COMP levels seen in dcSSc are most likely a reflection of more extensive fibrotic skin involvement, as the COMP found in the circulation in SSc patients is thought to be released from the skin.
We did not observe any changes of the baseline COMP levels over the 24-week period, thus there appears to be no long-term influence on the turnover of COMP induced by this physical exercise.
COMP levels were significantly increased in fibrotic lesions derived from patients with localized scleroderma, in wound tissue and exudates of patients with venous leg ulcers and in the fibrotic stroma of biopsies from patients with basal cell carcinoma.
Baseline COMP levels correlated strongly with end serum COMP levels.Serum COMP has the potential to be a prognostic marker of disease progression.
COMP levels in sera were measured by inhibition ELISA with monoclonal antibody (mAb) 17-C10.
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