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Concurrent comorbid analysis of the ADHD population may allow for a more comprehensive understanding of the vicissitude of this syndrome and assist in identifying potential endophenotypes.
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Overall, our comorbidity analysis and OMIM-based searches were limited to our ataxia interactome and 13 million patients and yet provided candidate proteins for a comorbid disease, MD.
Although we correct for comorbidity in our analysis, subtle differences in severity of comorbid conditions cannot be addressed and may result is residual confounding.
Analysis of comorbid psychiatric conditions could be performed only in the overall sample because of the small sample size of the BD-I group, considering the low rates of comorbidities.
Details regarding recruitment, diagnostic criteria and analysis of comorbid lesions (i.e. presence of vascular lesions) have been previously reported ([7], [11]; see next sections for details).
Therefore, we were not able to do further analysis on comorbid psychiatric diagnoses.
These analyses were completed to determine whether a single disorder (RD or LI) was driving association signals in the comorbid RD and LI analysis (Fig. 1).
Following our primary analysis of comorbid RD and LI, we next examined RD and LI individually to determine whether a single disorder was driving the association signals.
The revised guidelines did not address mammography use for older women or women with comorbid illnesses, so the analysis in Table 2 should not be affected.
In the subgroup analysis for comorbid conditions, no association was seen between longer hospital stay and decreased odds of 30 day mortality after discharge (web table 4).
In the bivariate analysis of comorbid disorders, only substance use disorder was associated statistically significantly with treatment: participants with substance use disorder had at least one visit with a physician more often than others.
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