Exact(2)
This bias against short transcripts could lead to a general under-representation in gene set testing for functional categories enriched in short genes (such as cell-cell communication, innate immunity, and signal transduction).
Our study is the most comprehensive analysis of the membrane proteome and N-glycoproteome in microglia, providing a rich resource that can be used to examine the functions of membrane proteins and their N-linked glycosylation with regard to microglial activities in the brain, including microglial activation, cell-to-cell communication, innate immune responses, and inflammatory activity.
Similar(58)
For example, the down-regulation effect of PT treatment is characterized by a suppression of genes related to communication between innate and adaptive immune cells, Fcγ receptor-mediated phagocytosis in macrophages and monocytes, antigen presentation and the role of hypercytokinemia/hyperchemokinemia in the pathogenesis of influenza pathways.
Whole genome microarray analysis of gene expression in lung tissue from PT-treated and control PR8-infected mice at 12 and 36 h post-virus inoculation revealed that PT treatment suppressed numerous genes associated with communication between innate and adaptive immune responses.
The communication between innate immune cells can be complex.
The importance of communication among innate immune cells has recently been emphasized in various immunity models.
Natural killer cell signalling and communication between innate and adaptive immune cells were identified as the top ranking canonical pathways.
These pathways include negative feedback mechanisms to prevent an excessive immune reaction, pathways governing cell fate decisions and communication between innate and adaptive immune systems [ 5, 6].
For example, significant enrichments of top 10 down-regulated pathways in AA patients included "communication between innate and adaptive immune cells" and "primary immunodeficiency signaling", whereas that in CAU patients were "interferon signaling" and "complement system" pathways.
From iDC to mDC, the pathways involved in communication between innate and adaptive immune cells, the complement system, and cross talk between DCs and natural killer cells were demethylated [see Additional file 5A].
The present review focuses on this intriguing two-way communication between innate and adaptive entities, a crosstalk that holds important implications on potential therapies for a multitude of immune disorders.
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