Small circular ssDNA viruses commonly replicate their genomes in the nuclei of infected cells via a rolling circle replication (RCR) mechanism initiated by virus-encoded replication initiation protein (Rep), and there are clear similarities among the sequences of these proteins [ 23, 24].
HSV-2 also commonly replicates in genital skin when lesions are not present, and is efficiently transmitted to other individuals at these times.
According to previous transethnic studies, the most commonly revealed variants were replicated in all of ethnic groups and have a species-wide role in biological pathways of hematopoiesis.
Their analyses replicated the commonly found relationship, even after including an earlier measure of academic achievement as a covariate; however, when they used a different technique, fixed effects analysis, which capitalizes on repeated measures data to control for time stable measured and unmeasured covariates, the observed relationships disappeared.
To study the mechanisms of TBI, the rat closed head impact (CHI) is commonly used for replicating the trauma events [ 3– 9].
Of course, it is also important to note that "me too" studies commonly claim to replicate high impact observations as a way of publishing follow-on observations.
Additive effects can be estimated if pedigree information is available for the genotypes, and, if genotypes are replicated as they commonly are in METs, non-additive effects can also be estimated.
Homozygosity for PTEN mutation was associated with a 20-fold increase in sensitivity to PARP inhibitors, which was replicated in a panel of commonly cultured tumor cell lines and in mouse xenografts.
There are regions in the mitochondrial genome replicated in the nuclear genome commonly known as nuclear copies of mitochondrial DNA (NUMTs), which would most likely be present as secondary alignments.
22 In order to compare to other commonly used methods of resting-state analysis, we replicated our data-driven results with a seed-based approach.
