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HPR is commonly regulated as the innate host immunity against Trypanosoma, a protozoan parasite [ 36, 37].
The clustered genes displayed similar expression patters which might indicate that they are commonly regulated as already reported for other clusters [ 34, 35].
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Further, DAVID analyses for the set of commonly regulated genes as well as for regulated liver genes (Additional file 6) yields GO biological processes that refer to steroid metabolism and, more specifically, to cholesterol biosynthesis.
In order to gain more insight into gene functions GO analysis was performed on the groups of commonly regulated genes as they were described in Table 1.
These authors identified 307 commonly regulated probes as candidate biomarkers of potential estrogenic activity.
This analysis revealed several biological processes that were commonly regulated across several different WOAs, as well as processes more specifically modulated by only some WOA or only at a few time points.
Since these commonly regulated pathways such as NRF2-mediated oxidative stress response, aryl hydrocarbon receptor signaling and metabolism of xenobiotics by cytochrome P450 pathways are part of xenobiotic metabolism signaling, xenobiotic metabolism signaling may play a pivotal role in the protection against the toxicity from the compounds.
First, p53 can modulate the TAp73/TAp63-mediated TAp73/TAp63-mediatedivating commonly regulatedrugnes such as presponseotic genes byx activatingr the commonlyip1.
Interestingly, MOX symbiont impacted a higher proportion of genes than SOX in both vent fields 14-200% vs. 8-16%, Table 2), as well as genes commonly regulated by each symbiont in the two vent fields (1.1% vs. 3% for SOX and MOX, respectively, Table 2).
Their functional analyses revealed several functional categories commonly regulated by both UV-B treatments as well as categories more specifically modulated depending on UV-B fluence rate.
Therefore, the presented list of commonly regulated genes in DLD1 and SW480 cells as well as the annotated list of previously published β-catenin target genes are useful resources for further studies.
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