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Since the cost functions of these estimators are not differentiable functions of parameters, they are commonly optimized by random sampling.
A crucial finding of this work is that the kinetics governing the covalently modified cycles in a signaling network are likely to be far more important for propagating an off-target effect due to retroactive signaling than the binding affinity of the drug for the targeted protein, which is a commonly optimized property in drug development.
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Automated parameter search methods are commonly used to optimize neuron models.
The most commonly used approaches optimize the prediction filters by minimizing the variance of the detail coefficients.
Thermal efficiency is a parameter commonly used to optimize the drying process since it is linked with the energy consumption.
Without going into detail, the mass transfer coefficient, K La is a function of agitation and aeration at the same time and is part of an equation commonly used to optimize growth conditions in modern bioreactor systems.
Genetic algorithm (GA) based on the evolutionary method of natural selection of the best individuals in a population is commonly used to optimize a given function over a certain range.
Most commonly, local methods optimize the cost function, Eq. (4), directly with respect to initial values x0 and parameters p. This optimization scheme is called initial value approach or alternatively single-shooting.
However, it is often questioned whether a truly quantitative RT-PCR method can be consistent among many laboratories, as it is commonly difficult to optimize and interpret [ 41, 44, 45].
Commonly, the survey design is optimized for robust estimates of regional status and trend detection and not necessarily to provide statistical inferences on the causal mechanisms outlined in the conceptual model, even though these relationships are typically used to justify and promote the long-term monitoring of a chosen ecological indicator.
Commonly the solar cell itself is optimized separately.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com