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For example, 8p region was consistently lost in HPIN (100%), but within the cytoband 8p11.23-p23.2 that was commonly lost in >50% of the HPIN samples.
Unexpectedly, no LOH was detected at several loci commonly lost in other human cancers (namely 3p, 9p, 9q, 13q, 16q, 17p, and 17q) in 12 tumours examined.
The chromosome 17 containing a relatively high density of genes was commonly lost in intestinal-type cancers but not in diffuse-type cancers.
Although peptide-altering mutations of RIZ are rare in HCC, the RIZ1 product is commonly lost in HCC and has tumour suppressive activities.
Similarly, 8p was consistently lost in CaP (100%), but within the cytoband 8p11.22-p23.2 that was commonly lost in >60% of the CaP samples.
MutS, a critical component of the mismatch repair system [ 20], is commonly lost in hypermutator strains [ 19], resulting in elevated mutation rates [ 21].
Similar(41)
Another study conducted in head and neck cancer patients reported increased methylation of p16 INK4a, a gene involved in cell cycle regulation that is commonly lost or silenced in head and neck cancer via epigenetic mechanisms, in those consuming the lowest levels of folate compared with the highest levels.
The "commonly lost" COGs are "COGs lost in concert among all test groups", i.e. core of lost COGs.
In humans, the hTRM9L gene maps to the end of human chromosome 8, a region commonly lost or silenced in many different cancers, including colorectal carcinoma (Ilyas et al, 1999; Kerangueven et al, 1995; Knowles et al, 1993; Prasad et al, 1998).
A list of the genes present within these consensus or commonly lost regions is displayed in Table 3. Chromosome copy number abnormalities (CNAs) are common in most cancers, with specific regions of amplification or deletion being associated with specific tumour types, stages or outcomes [ 16- 18].
Part of the murkiness in the description may result from difficulties in the use of English, for instance the many missing articles, and does "commonly lost" mean "often observed to be lost" or "lost in concert among all test groups"?
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