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The commonest grade 3 4 toxicities were lethargy (20%), diarrhoea (17%), nausea (10%) and anorexia (10%).
The commonest grade III/IV chemotherapy-related toxicities were diarrhoea, neutropaenia and palmar plantar syndrome (Supplementary Table 2).
Commonest grade 1 or 2 toxicities encountered in both groups were malaise, in 46.7% of patients, followed by alopecia (20%), and nausea (10%).
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Although this is likely, at least in part, to be a reflection of the era in which the patients were recruited to the trial, high-grade DCIS remains the commonest form identified in the United Kingdom.
Type 1 SMA, the commonest form, is the most severe.
The cutaneous form is the commonest form.
The commonest toxicities were lethargy (≥ grade II, 10 patients), constipation (≥ grade II, 11 patients) and neuropathy (≥ grade II, 5 patients).
Osteosarcoma (OS) is the commonest high-grade primary bone malignancy.
The commonest subtype, ovarian high-grade serous cancer (HGSC), is usually diagnosed after the disease has disseminated throughout the peritoneum, and as a result, 5-yr survival statistics are poor (UK 43%; ref.22).
Applying Lown's grading of PVC 14 among patients with PVC, Lown's grade 2 was commonest in the HHD without heart failure (35.3%) and T2DM (10.3%) patients, while Lown's grade 4 was commonest among HHF patients (51.5%).
Fatigue was the commonest treatment-related toxicity and it resulted grade I in 18 patients, grade II in 22 patients and grade III in one patient.
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