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Sequencing in Gambians has suggested that 1264G and 1444delA are the commonest deficiency alleles in this population, with others being <1% frequency (12).
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The commonest deficiencies include iron, lack of which causes fatigue and anaemia, iodine (developmental delay), Vitamin D (poor growth and rickets), vitamin A (night blindness) and zinc (poor wound healing).
The commonest reported African CD36 deficiency allele is a nonsense mutation in exon 10 of CD36 (T1264G; rs3211938), which terminates the polypeptide before the second transmembrane domain (12).
Iron deficiency is the commonest nutritional deficiency worldwide, affecting ∼50% of the world population (4).
Iron deficiency is the commonest cause of anaemia but other causes include nutritional deficiencies, bone marrow suppression and haemolytic or hereditary diseases.
Although iron deficiency is the commonest cause of nutritional morbidity worldwide (Stoltzfus 2003), in women of reproductive age concurrent deficiencies of vitamins A, C, B and folate also frequently occur and all contribute to an increased anaemia risk (Huffman SL et al 1998).
Folate deficiency is one of the commonest forms of vitamin deficiency and is also associated with cerebral cortex atrophy (Snowdon et al 2000).
Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21-OH) is the commonest cause of DSD in 46,XX individuals.
Iron deficiency is considered to be the commonest worldwide nutritional deficiency and affects approximately 20% of the world population.
The commonest fatal liver disease in childhood is a congenital deficiency of bile ducts called biliary atresia.
Iron deficiency anemia (IDA) is one of the commonest nutritional deficiencies globally, with young children, women of childbearing age and pregnant women at highest risk [1].
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