Moreover, similar clinical parameters and a highly aggressive course of disease for all ETMR histological variants (resistance to treatment, inevitable tumor recurrence and rapid death) also support our suggestion of commonality [ 1, 8, 9, 11, 15, 16, 19].
We note that some investigators intentionally drew on the materials used by prior studies, establishing areas of commonality [ 1, 12, 60].
Two genes (PDE3B and GADD45a) found to be differentially expressed in PBMCs of CP patients were also differentially expressed in PBMCs of PC patients, neither of which being differentially expressed in the same direction (0% commonality) [12].
Furthermore, the intriguing observation that the adenohypophysis is transformed into an ectopic lens in the zebrafish midline mutants you-too (yot) and iguana (igu) by a mutation in Gli2 gene, is additional evidence for developmental and molecular commonality [24].
Twelve genes (BTG2, CCND3, CD151, CD7, CLU, CTSB, KLRK1, SPN, GSTO1, PCMT1, PRDX6, and PRF1) that were shown to be differentially expressed in PBMCs of patients with RA were also differentially expressed in PBMCs of PC patients, 8 of which (CCND3, CD151, CLU, CTSB, GSTO1, PCMT1, PRDX6, and PRF1) were in the same direction (2% commonality) [11].
In total, 6 genes (CD160, GOLGA8B, RABGAP1L, MMP8, CRISP3, and ARG1) that were shown to be differentially expressed in PBMCs of patients with pre-eclampsia were also differentially expressed in PBMCs of PC patients, with 4 (CD160, MMP8, CRISP3, and ARG1) being differentially expressed in the same direction (1% commonality) [10].
In total it was found that, of the 383 differentially expressed genes found in PBMCs of PC patients, only 4 (ADAM9, IMP3, BTG2, and G6PD) were also shown to be differentially expressed in PC primary tissues, with 2 (andM9 and BTG2) being differentially expressed in the same direction (0.5% commonality) [30].
Interestingly, within the cluster that overlaps between the fetal and the adult subsets, the UGE+Sca-1Hi cluster, we found substantial numbers of transcripts (209) that were commonly up-regulated, while lesser commonality (112 transcripts) was observed in the cluster that overlaps (Sca-1Hi+Sca-1Lo cluster) between the APSC subset (Sca-1Hi) and the TA subset (Sca-1Lo) (Figure 1, Table S2).
In contrast, network functions enriched among protein and transcript results indicated a greater degree of commonality (42, 36 and 27 % for female liver, male liver and male kidney tissues, respectively) in the 30 mg/kg-d dose treatment (Fig. 1f).
The greatest degree of commonality in DET was found between the 1.8 and 7.2 mg/L RDX treatments (25.5%), followed by the 0.5 and 1.8 mg/L treatments (14.9%) whereas the least commonality (10.5%) was found among the most disparate RDX-exposure concentrations, 0.5 and 7.2 mg/L.
However, Lucas et al found that textual narrative synthesis is 'less good at identifying commonality' (p2); the authors do not make explicit why this should be, although it may be that organising according to themes, as the thematic approach does, is comparatively more successful in revealing commonality.
