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The study, published in the Lancet Oncology journal, listed common "toxic" effects of radiotherapy on the heart, lungs and stomach were not seen in those undergoing proton treatment.
Neutropenia and neuropathy were the most common toxic effects of the combination.
Nilotinib was not associated with the common toxic effects seen with imatinib such as fluid retention, edema, cramps, and weight gain, or with pleural effusions.
Notably, cetuximab did not dramatically exacerbate the common toxic effects associated with radiotherapy of the head and neck, including mucositis, xerostomia, dysphagia, pain, weight loss, and performance status deterioration.
As defined, aggregate exposure is the extent of contact and exposure of a defined population to a given chemical by all relevant routes and all relevant sources, and cumulative exposure is the extent of contact or exposure of a defined population to multiple chemicals with common toxic effects found in at least one media and one or more sources (U.S. EPA 2001, 2003).
The authors hypothesized that the lack of activity could be related to an inadequate blood concentration of vandetanib, although most patients achieved plasma concentration above the IC50; however, the common toxic effects for VEGF inhibitors (for example, hypertension, headache, and thrombosis) and for epidermal growth factor (severe rash) were not seen in this clinical study.
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The most common toxic effect was myelosuppression, and this toxicity was the main reason for treatment interruption and dose reduction.
Oral mucositis, a severe oral ulceration, is a common toxic effect of radiation for bone marrow transplant and upper body radiotherapy or chemo-radiotherapy for all cancer types (Sonis, 2010; Vagliano et al., 2011).
Oral mucositis, a severe oral ulceration, is a common toxic effect of radio- or chemoradio-therapy and a limiting factor to using the maximum dose of radiation for effective cancer treatment.
Acneiform rash is the most common toxic effect.
46 The most common toxic side effects associated with TMZ are nausea, vomiting, fatigue, and hematologic toxicity.
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