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The fact that conventional protein structural comparison (PSC) methods are weak at specifically identifying domain-swapped homologs implies that detecting DS relationships is a very different problem from detecting common structural similarities between proteins.
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Furthermore, the closely matching NMR and HPLC data of dioxobilane 1 and the isomeric Hv-UCC-1 also indicate their mutual structural similarity to include common relative configurations at C-15 and at C-13, as well as at the two further stereocenters C-1 and C-9 of the tetrapyrrole skeleton (see Table SI in the Supporting Information).
Members of the NLR family share common structural and functional similarities with the TLRs, which include a carboxyl-terminal LRR; a central nucleotide binding domain (NACHT) domain, which has intrinsic ATPase activity; and an amino-terminal protein-protein interaction domain, which contains either a caspase activation and recruitment (CARD) domain or a baculovirus inhibitory repeat domain [ 12].
As protein folding and function is significantly contributed by hydrogen bonds, it is conceivable that both monocot and dicot AGPase SS share a common structural and functional similarity with that of the template protein.
Interestingly, a pair of common structural homologs with a high structural similarity also has a low DS score as well because its γθ and γd cannot be large, in addition to the fact that η can be zero when no hinge loop is detected.
We have observed that many paths common among PDF files exhibit structural similarities to other paths.
We aimed to synthesize existing datasets characterizing ASD and schizophrenia within a common framework, to quantify their structural similarities.
Its converse – structural similarities imply common heritage – is often used to predict the function of unknown proteins and genes.
Glypicans form the second most common HSPG group, and have structural similarities to syndecan, typically differing only in the number of GAG attachment sites while perlecan remains in the basement membrane as discussed earlier [ 41].
Although dependence receptors display functional similarities, no common structural domains have been identified.
A central tenet of structural biology is that related proteins of common function share structural similarity.
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