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The common structural fragments of artemisinin skeleton are displayed by green blue which contribute positively to the model (Fig. 5).
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We used the computer system SARD-21 (Structure Activity Relationship & Design) to investigate common structural features (fragments and substituents) typical for high- and low-effective non-steroid anti-inflammatory drugs (NSAIDs) succesfully.
The method is designed to recognize one or more common "structural markers", corresponding to mass spectral fragments originating from the specific portion of the molecular structure that is common to the aminoalkylindole analogues and that is fundamental for their pharmacological classification.
The results indicate that SE and CYP51 inhibitors have common structural feature with two parts of essential fragments, which are mainly composed of aromatic groups.
The Structure Space is the collection of structural fragments from which we can select the candidate structural fragments for a sequence segment.
Repository of structural fragments: The fragments are extracted from protein structures in PDB.
Jones, D. T. & McGuffin, L. J. Assembling novel protein folds from super-secondary structural fragments.
FRAGFOLD assembles folds from a mixture of supersecondary structural fragments and short fixed length fragments taken from a library of highly resolved protein structures using a simulated annealing approach.
Crowther, R. A. Straight and paired helical filaments in Alzheimer disease have a common structural unit.
The ankyrin repeat: a diversity of interaction on a common structural framework.
Therefore, there might be a common structural basis for constipation and apathy for PD patients.
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