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The ecotoxicity of binary chemical mixtures with a common mode of action is often predicted with the concentration addition model.
The most common mode of action in the field of synthetic biology is mediated by synthetic gene circuits assembled in a systematic and rational manner.
This convergence in structure of the top performing polymers suggests a common mode of action and provides a framework with which future polymers can be designed.
A Metascape analysis of all RNA-Seq data of downregulated RNAs in response to the toxic siL3, si34a-5pSeed, miR-34a-5p, and threehree genotoxic drugs suggested a common mode of action (Supplementary Fig. 9d).
Gene expression changes caused by all three triazoles in liver and hepatocytes were concentrated in biological pathways regulating lipid, sterol and steroid homeostasis, identifying a potential common mode of action conserved between rodents and humans.
The results show that a simple rationally designed model β-sheet peptide recapitulates many important features of Aβ peptide structure and function, reinforcing the idea that toxicity arises, at least in part, from a common mode of action on membranes that is independent of specific aspects of the amino acid sequence.
The common mode of action is the smelling of the active ingredients.
Nanosensors exhibit numerous operating principles [100] but a common mode of action is conversion of physicochemical properties into signals.
Tier 2 Assessment: Defined in WHO approach to mixtures as a refined assessment that only assumes additivity with in groups of chemicals where a common mode of action occurs.
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Additionally, we demonstrate that lacticin 481 does not form pores in the membranes of susceptible bacteria, a common mode-of-action of other lantibiotics.
The most common mode-of-action for many bioactive venom toxins with clinical potential is the blockage of ion channels [18].
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