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The use of dominant drug targets should suppress drug resistance whenever multiple genomes arise in the same cell and express products in a common milieu.
In addition to endogenous production of MTR, these species likely can transport it from organisms like E. coli which excrete it into the common milieu.
This could indicate a clonal relationship, but another possibility is that their development in a common milieu and genetic background could lead to pathogenetically similar tumors that are in fact independent cancers.
We favour this interpretation over the hypothesis that a common milieu may have given rise to two clonally independent, but pathogenetically identical, breast carcinomas (Imyanitov et al, 2002); if this was a relevant mechanism in breast carcinogenesis, pathogenetically similar bilateral breast carcinomas should be the rule, not the exception.
Similar(56)
But they occupied a common intellectual milieu.
This interrogation focuses on historical and cultural processes that enabled this masculinization, certain ideals of femininity implicit within this narrative which opens the door for female participation, and womens' use of images and icons drawn from a common cultural milieu to enter the political landscape of Hindutva.
Yusufi, It seems that the financial challenges mosques and synagogues presently face are surprisingly similar--presumably, living in a common American milieu is the reason for this.
Whether it's the "New Atheists" - men like Dawkins, Hitchens, and Harris - and their jeremiads against religion, or the "common sense" milieu of our age that takes for granted the value of moderation in all things, most especially religion, religious zeal appears as an obvious evil.
The association between LAP, liver steatosis and cardiometabolic disease [ 15, 16] might be partially explained by a common pathophysiological milieu.
When phenotypic switching of smooth muscle cells to an osteogenic phenotype is achieved in vitro using a common osteogenic milieu, it involves cell differentiation and expression of alkaline phosphatase to hydrolyze phosphoric acid monoesters into free phosphate ions [ 35].
Each gene has its own promoter and its own idiosyncratic response to a common transcription milieu [ 58, 59], and each agonist acts upon different classes of receptors and therefore acts differently on the available inducible genes.
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CEO of Professional Science Editing for Scientists @ prosciediting.com