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Here, we identify common interactions of LRRK2 with members of the dynamin GTPase superfamily.
Finally, Tanrikulu et al. used a structure-based pharmacophore model based on the common interactions of four PPARγ X-ray crystal structures in complex with different agonists [143].
When comparing different networks a network similarity (NS) measure was devised: where A and B represents different networks, SAB the similarity (i.e. the frequency of common interactions) of A versus B, and SBA the similarity of B versus A. Networks were visualized using Biolayout [ 66] and Cytoscape [ 67].
Additionally, downregulation of ACTR1B (p = 0.012) and FASN (p = 0.007) was verified.> -wrap-foot>> -wrap-FCot> Foldold change FC Fold change Furthermore, qRT-PCR analyses were performed in order to validate the network showing common interactions of HN1957 and HN2092 in response to radiochemotherapy-treatment (Fig. 5).
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The circularization is thought to be caused by the common interaction of the cap-binding protein eIF4E and the polyA tail binding protein (PABP) with the scaffolding protein eIF4G.
Furthermore, we have confirmed a common interaction of MUPP1 and LNX1/LNX2 with EphA7.
We detect a common interaction of LRRK2 with Dnm1, Dnm2 and Dnm3 (Fig. 1B).
We also confirmed the common interaction of LNX1, LNX2 and MUPP1 with EphA7 and show that EphA7 can bind, not only to an isolated LNX1 PDZ domain [ 42], but also to full-length LNX2 and near full-length LNX1 proteins.
For any combination of two releases, prediction overlap was calculated as the ratio of the number of common interactions to the total number of unique interactions predicted using both releases.
Based on our findings an exploration of common interactions and cellular functions of LNX1/2 and MUPP1 is merited.
Analysis of cytoplasmic fractions showed the presence of 4 common interaction partners of Hsp60 (including H2B and Hsp70) within the cytoplasm at the different temperature conditions, comprising 40, 3.7, and 3.3% of all the interactions observed at 30, 37, and 37/40°C, respectively.
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