These focused on one kind of genetic variant, known as single nucleotide polymorphisms, and only those that are quite common in the population.
Further reducing the hapmap's reach, the haplotype approach is likely to find only the disease-causing variant genes that are reasonably common in the population.
The problem addressed in the commentaries is that these diseases were expected to be promoted by genetic variations that are common in the population.
A principal theory has long been that these variant genes have become common in the population because the diseases strike late in life, after a person has had children.
Structural abnormalities of the autosomes are even more common in the population than are numerical abnormalities and include translocations of large pieces of chromosomes, as well as smaller deletions, insertions, or rearrangements.
A computer program then matches the billions of 32-unit fragments to the completed human genomes already on file and records the sites at which there are additions or deletions to the standard sequence, or a different DNA unit from the one most common in the population.
Yet Marfan syndrome, caused by a mutant gene, afflicts one in 5,000 to one in 10,000 people, making it as common in the population as much better known genetic conditions like sickle cell anemia and more common than cystic fibrosis and hemophilia.
The subjects were all mostly Mediterranean Caucasians, but interracial marriages are common in the population that was sampled.
In spite of neck disorders being so common in the population, little evidence supporting effective interventions has been identified.
Let's say that, for whatever reason, one of the host genotypes is very common in the population, while the rest are rare.
A third strategy is to filter out variants with e.g. MAF >0,1%, thereby excluding variants common in the population from the study data [37, 38].
