To circumvent the negative effect of preexisting immunity to common human serotypes of adenoviruses on the efficacy of adenovirus vaccine carriers, we developed vectors based on chimpanzee-derived adenoviruses C68, C6, and C1 (8 ).
This test utilizes a genus-specific monoclonal antibody to detect epitopes common to all human adenovirus serotypes.
Chimpanzee adenoviruses have been considered ideal carriers for the development of vaccines against a broad range of pathogens because their neutralizing antibodies are rare in humans, and this low antibody prevalence would circumvent the negative effects of pre-existing immunity to common human serotypes of adenovirus.
The hexon capsid protein appears to have some antigenic sites that are common to all human adenoviruses and contains other sites that show type specificity [ 73].
Human adenovirus (HAdV) infections, while common in infancy and childhood, occur rarely in the neonatal period but may be fatal.
RSV and human adenovirus were the most common respiratory viruses detected by rt-RT-PCR.
It contained probes for several common human respiratory viruses and bacteria, including influenza, adenovirus, coronavirus and rhinoviruses, together with bacteria such as Bordetella pertussis and Streptococcus pneumoniae.
Human adenovirus (HAdV) is one of the most common pathogens associated with viral ARI, and thus calls for specific diagnosis and better understanding of the epidemiology and clinical characteristics.
HAdV-F is the only human adenovirus species that harbors 2 fiber genes, a feature common in macaque adenoviruses, including HAdV-G members; however, SAdV-18 differs from HAdV-F members in possessing a single fiber gene.
Human adenovirus type 37 (HAdV-37) is a major etiologic agent of epidemic keratoconjunctivitis, a common and severe eye infection associated with long-term visual morbidity due to persistent corneal inflammation.
