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Genetic alterations in signaling pathways that control cell-cycle progression, apoptosis, and cell growth are common hallmarks of cancer, but the extent, mechanisms, and co-occurrence of alterations in these pathways differ between individual tumors and tumor types.
Our findings could be valuable for designing alternative therapies to alleviate the clinical manifestation of the cblC disorder, as some of the protein changes detected in our study are common hallmarks of known pathologies such as Alzheimer's and Parkinson's diseases as well as muscular dystrophies.
Invasion and metastasis is one of the most common hallmarks of cancer, especially those with high grade malignancy.
Alongside known genetic changes, aberrant epigenetic alterations have emerged as common hallmarks of many cancers, including glioblastoma.
Aberrant DNA methylation and chromatin modifications, altering gene transcription states, are common hallmarks of human tumour cells [ 24].
Morphological abnormalities in dendritic arbourization and postsynaptic structure are common hallmarks of a number of cognitive diseases, for example, mental retardation (Bagni and Greenough, 2005).
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Axon degeneration is a common hallmark of many neurodegenerative diseases.
Fraga, M. F. et al. Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer.
Oxidative stress is a common hallmark of neuronal cell death associated with neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, as well as brain stroke/ischemia and traumatic brain injury.
Altered expression of microRNAs is a common hallmark of cancer that we demonstrate can be used to alter expression of a potent wild-type viral gene to achieve tumor-specific replication of an engineered vesicular stomatitis virus (VSV).
The most common hallmark of the left's magical thinking is a failure to recognize that Congress is a separate, coequal branch of government consisting of members whose goals may differ from the president's.
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