Structurally, however, CAR shares common functional features with other typical nuclear receptors, including a highly variable N-terminal AF1 domain, a DNA binding domain (DBD), a ligand-binding domain (LBD), and a C-terminal AF2 domain.
Then, it organizes the large set of genes based on common functional features, like GO categories or biochemical pathways [ 8].
If scramblases and tubby proteins are distantly related, we might expect to find some common functional features.
Continued identification and classification of DAM genes from additional species is needed to identify the common functional features of clades of these sequence-specific proteins.
On the other hand, disease associated genes tend to share common functional features, be co-expressed in specific tissues, and their protein products have a tendency to interact with each other [ 8].
All domains are predicted to have a high content of α-helices that co-align in the multiple sequence alignments, reinforcing the prediction of sequence similarities and suggesting that these domains form folded structural units that may share common functional features.
It was found that there were common functional and technical features, as well as similar performances of existing buildings linked to these buildings' energy consumption.
Once these sets of aggregation-prone proteins were identified, we looked for common functional or structural features.
In fact, all transporters from the SLC17 family except SLC17A1 which transport p-aminohippuric acid across renal apical membrane[ 52] that have been functionally investigated are to our knowledge - a vesicular transporter, which suggests that the location to vesicles is an ancestral functional feature common for the SLC17 family.
These cells, which have been presumed to be of common embryological origin from the ectodermal ridge, spread throughout the body to form a network with common structural and functional features.
