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Analysis of protein superfamilies through explicit mapping of common functional characteristics to conserved structural elements among very distantly related homologs provides a valuable conceptual approach to connecting sequence, structure, and function in ways that are important for understanding both natural and laboratory-based protein engineering.
These up- or downregulated proteins can be grouped into 13 classes based on their common functional characteristics, indicating that IrrE plays a global regulatory role in gene expression in E. coli (Figure 4, Table S1, S2).
If the latter is true these expression patterns may represent outputs of molecular events which have led to common functional characteristics of cancers.
Interstitial lung diseases (ILDs) are a heterogeneous group of more than 200 different serious disease entities with common functional characteristics such as restrictive physiology and impaired gas exchange, and with variable degrees of pulmonary inflammation and fibrosis [ 1, 2].
Similar(56)
Grouping was mainly aimed at recognizing common potentially functional characteristics in the sequences of groups of HD-Zip I proteins.
The results reveal similar protein flexibilities and suggest common dynamic and functional characteristics.
The present results demonstrate the existence of a bacterial TSPO that shares common structural and functional characteristics with its mammalian counterpart.
Tumors are usually defined according to their common morphological and functional characteristics, such as abnormal growth, immortality, invasion etc.
Overall, the comparative analyses of intronless genes among Poaceae species clearly showed several common functional and evolutionary characteristics that may also be found in other major eukaryote kingdoms.
Our results demonstrate that pathway profiles can successfully characterize both common and distinct functional characteristics of four subtypes of breast cancer and other related diseases, with acceptable reproducibility, high accuracy and reasonable resolution.
Given that 5' UTR introns are relatively rare it will be of interest to see whether the subset of genes that do possess them have any functional characteristics in common.
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