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Taken together, these results suggest that proteins with KAHRP-like architecture follow a common export pathway, but that PfEMP1s utilize an alternative pathway.
While the majority of proteins with a signal/hydrophobic sequence preceding the PEXEL/VTS motif may utilize a common export mechanism, the export of PfEMP1 appears to employ an alternative mechanism, which may be unique to P. falciparum.
These results suggest that the majority of exported plasmodial proteins, which have a Type 1 N-terminus, utilize a common export pathway, but that PfEMP1 export differs from this common pathway.
Export of GFP into P. berghei-infected erythrocytes by Type 1 N-termini of both P. falciparum and P. berghei exported proteins suggests the presence of a common export pathway in Plasmodia.
The presence of a common export mechanism in malaria parasites is also supported by conservation of the components of a recently discovered transport complex in the parasitophorous vacuole membrane (PVM) of P. falciparum, which has been proposed to be required for protein export [20].
These data indicate that KP1339 and sorafenib share a common export mechanism.
Similar(52)
Independent export channels are the most common exporting entry mode, although the lack of ownership hinders their management and affects export performance.
In this regard, the here presented work analyses, in silico, five C. pseudotuberculosis genomes and gathers data to predict common exported proteins in all five genomes.
We've been working with the team at Google to try to resolve this, and will revisit a Creative Commons export if a workable solution is found.
Functional validation of common putative export domains of malaria parasites in P. berghei provides an alternative and simpler system to investigate export mechanisms.
Functional validation of common putative export domains of malaria parasites in P. berghei provides an alternative and simpler system compared to P. falciparum to investigate export mechanisms.
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