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IVT-AFL 2q8 and IVR 0.5 mg PRN could be directly compared via a common comparator of laser (plus sham injection) in four studies [ 13, 15, 16].
If licensing studies were controlled with placebo or a comparator not relevant to standard care in England, modeling may be used to indirectly compare study arms from separate studies with a common comparator (Section 2.5 GMS TAPS 5).
Adjusted indirect comparison is a way to compare two compounds through their relative effect vs. a common comparator (placebo in our study).
In contrast to direct within-trial comparison, in indirect comparisons, the effects of interventions are compared to each other by their performance against a common comparator.
The sufficiently comparable studies were combined into a network analysis based on a common comparator.
Indirect comparison based on a common comparator can preserve certain strengths of randomised allocation of patients for estimating comparative effects of treatment.
26 This approach will be used to integrate direct evidence (from studies directly comparing interventions) with indirect evidence (information about two treatments derived via a common comparator) from multiple treatment comparisons to estimate the interrelations across all treatments.
Despite of the specific methodology, a common comparator is required in adjusted indirect comparisons [1]-[4].
Non-adjusted indirect comparisons (i.e. comparisons based on studies without a common comparator) are considered inacceptable.
As well as in England and Scotland, Placebo was the common comparator.
Letter A to F are representing trials, X is common comparator.
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