Two varieties, FL7600 and PI114490 share a common haplotype at this locus, while OH9242 has a second haplotype.
Our results suggest that common SNPs at this locus can also contribute to normal variation in the timing of tooth eruption and craniofacial distances.
In contrast to eutherians, monoallelic expression of L3MBTL, HTR2A and MEST is maintained in tissues derived from the three germ layers (liver, brain and kidney), whereas polymorphic imprinting is common at these loci in eutherians [ 1].
We conclude that common coding variability at this locus does not explain the association, and that there is no large effect of common genetic variability on expression in brain tissue.
Trinucleotide CGG-repeat expansions, resulting in FMR1 gene silencing, are the most common mutations observed at this locus.
Whether common genetic variation at this locus affects cardiac structure, function, and ischemia in humans is not known.
Although common hexanucleotide indels at this locus are clinically benign, any pathogenic mutation present in cis would probably be missed using a conventional approach for variant detection.
Common genetic variants at this locus have been associated with accelerated aging and cognitive decline (Johnson, 2006; Davies et al., 2014), possibly by increasing the risk for coronary artery disease, stroke and AD (Smith, 2002).
From our result, the biotype a strains shared a single common allele at locus SS13 whereas two common alleles were detected at this locus for S. sonnei biotype g.
Interestingly, the haplotype CATATAC (χ = 3.94; P = 0.047) and its 4-mer derivative CATA was also implicated, albeit less significantly so in T2DM, pointing to MI and T2DM sharing common causative genomic sequences at this locus.
