CD64 expression is common in APL but is highly variable.
Although no study has been conducted to determine whether HZ is more common among APL patients who receive arsenic trioxide versus other treatments, physicians have commented that only the patients treated with arsenic trioxide developed HZ (Tanvetyanon and Nand 2004).
These data suggest that activation of HIF factors may be a common event in APL.
Any positive aPL were more common in this study (65%) than reported in most [ 7, 33, 42] lupus cohorts possibly indicating a low cut-off level at our laboratory in the mid 90's when baseline data were collected.
In this study we examined the ability of a synthetic peptide (named peptide A, NTLKTPRVGGC) that shares similarity with common bacterial antigens, to reverse aPL-mediated thrombosis in mice in vivo.
Although the mechanisms of thrombosis may be different, previous studies point to complement activation and inflammation as common mechanisms in LN- and aPL-associated vascular pathology.
In conclusion, the prognostic information conveyed by plasmatic PAF-AH activity in patients with positive aPL antibodies appeared to be independent of common lipid metabolic markers (i.e. LDL), as previously reported by other authors in the context of patients with major coronary events [11].
In addition to mzML, it also supports other common mass spectra data formats: dta, ms2, mgf, pkl, apl (text-based), mzXML and mzData (XML-based).
More recently, clinicians have identified HZ as a common side effect for patients with acute promyelocytic leukemia (APL) after they received treatment with arsenic trioxide (Au and Kwong 2005; Douer and Tallman 2005; Nouri et al. 2006; Rousselot et al. 2004; Subbarayan et al. 2007; Tanvetyanon and Nand 2004).
The PML gene was first discovered as the fusion partner of the retinoic acid receptor alpha in a common translocation found in the promyelocytes of patients with acute promyelocytic leukaemia APL;(de Thé et al., 1991).
