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Time delays are common and substantial in biochemical process.
Time delays are common and substantial in these biochemical processes due to gene transcription, translation, posttranslation protein modification and diffusion.
Pointing out that time delays are common and substantial in gene regulatory networks, Chen, et al.[ 50] proposed a method to design robust gene regulatory networks under biochemical timing variations and molecular noises.
A decline in function is however common and substantial, where a three times larger decline in function during a year has been reported for those who experienced a hip fracture as compared to those who did not [ 4].
These findings vindicate, on a much larger data set and with greater confidence, the previous conclusions that compared to the common and substantial intron loss, extensive intron gain was rare during the evolution of eukaryotes.
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SAB is common, and a substantial proportion of cases may be preventable.
Both case diseases are increasingly common and present substantial problems to health care agencies.
Gastrointestinal (GI), respiratory and dermal symptoms are common and cause substantial morbidity, although the information on their exact incidence and comparative burden is limited.
To improve the predictive ability of clinical risk models for complex diseases, genetic variants must be common and have substantial effect on disease risk.
ETS is still common and creates substantial health costs; for instance Switzerland spends an estimated 419 million Swiss Francs in health costs due to ETS exposure [ 4].
Chronic kidney disease (CKD) is common and causes substantial morbidity, mortality and healthcare expenditure because it is associated with an increased risk of cardiovascular events as well as progression to end-stage renal failure.
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