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All procedures performed in the study were in accordance with the ethical standards of the institutional research committee (date of issue 21 August 2014, registration number 2014-60) and with the 1964 Helsinki declaration and its later amendments.
The study had a non-interventional design and was approved by the regional ethical committee (date of issue: October 11, 2004; registration number: 517-04197).
These experiments were carried out within the context of institutional guidelines for care and treatment of experimental animals, and after approval by Linköping ethical committee (date of issue: March 30, 2004; registration number: 33-04; andatete of issue: November 21, 2006; registration number: 63-06) The rats were anesthetized with 5% isoflurane gas.
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