These early embryonic events are also observed in ESCs, in which mesodermal commitment is defined by the upregulation of the Bry gene within 48 hours after the onset of differentiation [ 9].
We thus performed a more systematic survey of the extent of ZEB1 binding to genes previously involved in adipogenic commitment, as defined by (1) a specific 3T3 pre-adipocyte expression signature (Gupta et al., 2010) and (2) pre-adipocyte factors found to be regulated at the expression level (recently compiled in Cawthorn et al., 2012).
"This is my vision of the future Europe," Mr. Berlusconi said in an interview, suggesting that membership should be defined by commitment to democracy, global security and certain values, not traditional continental geography.
His career is defined by lengthy commitments to organisations: 14 years at Wigan, 10 years at Wasps, and now nine with the WRU.
In 1954, when he was 28, William F. Buckley Jr. founded National Review to bear the standard of a fledgling conservative movement defined by three commitments: to fight Communism, to diminish the federal government and to uphold traditionalism in social affairs.
They just have a different view of what makes America special.Liberals think that America has been defined by its commitment to equality of opportunity (hence their worries about cutting inheritance tax); by its commitment to the separation of church and state (hence their worries about faith-based social policy); and by its enthusiasm for human rights (hence their worries about torture).
Kirk's life was defined by his commitment to family.
Soap operas are defined by a commitment to insularity — atmospheric, relational, with circular narratives.
In contemporary literature and music, the ballad is primarily defined by its commitment to nostalgia, community histories, and romantic love.
In a democracy, where freedom of association and speech are core rights and should be rigorously defended, the ethics of protesting should be defined by a commitment to embody in the protest itself the very norms that sustain democracies.
