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However, a suggested function of these proteins, mediated by their mutual interaction, is to prevent the mitochondrial release of factors controlling activation of caspases and thus the irreversible commitment to undergoing apoptosis (Jacobs and Marnett, 2009).
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What shred of fame Toby Sheldon enjoyed came from a thoroughly modern commitment: to undergo a bevy of plastic surgery procedures so that he could resemble Justin Bieber.
Participants in this study cannot be considered a random sample of the very old population; they had elected to participate in the Newcastle 85+ Study and made a subsequent additional commitment to undergo cardiac assessment.
Cleavage of PARP effectively neutralizes its ability to participate in DNA repair and contributes to the commitment of a cell to undergo apoptosis.
The most common reasons for not participating in the study were time commitment and not wanting to undergo an MRI scan.
Examining the skin of K14Cre/C8flox/flox animals, we found that loss of caspase-8 expression is associated with a deficient commitment of the basal cells to undergo terminal differentiation.
Are actively dividing stem cells more likely to undergo lineage commitment than quiescent stem cells?
A considerable time commitment is required when opting to undergo TKA.
On this basis, we propose, the 'last cell standing hypothesis' in which PGCs are derived from the last cells in the embryo that are to undergo lineage commitment.
The transcription factor p63 is one of the most important regulators of skin homeostasis and, similar to conditional deletion of Setd8 in E18.5 embryos, embryos lacking p63 fail to undergo epidermal commitment (Koster, 2010).
Consistent with this, our data show greater specificity of Gfi1-35 acomparedcompared to the Scl+19 in day 4 EBs for cells undergoing commitment to the haematopoietic lineage.
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