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Our interpretation of the experimental data was supported by a Monte Carlo simulation of the two opposing models, namely that selection of eventual neuronal or non-neuronal fates depends upon events occurring before or co-incident with induction of differentiation, rather than following cell commitment to differentiate.
We honor that commitment, to differentiate our relationship, no matter what.
Abnormal EVI-1 expression probably contributes to AML by interfering with other genes controlling the commitment to differentiate.
Next, we examined whether culture of EBs in a low oxygen environment affected their commitment to differentiate into a specific lineage.
Indeed, MEK inhibition on normal stem cells (induced pluripotent stem cells and embryonic stem cells) maintains self-replication of the pluripotent state and inhibits their commitment to differentiate.
Commitment to differentiate into specific lineages requires strict control of gene expression to coordinate the downregulation of lineage inappropriate genes while enabling the expression of lineage-specific genes.
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The later appearance of the H4R3me2a modifications specifies the onset of neurogenesis and gliogenesis and the commitment of the NSCs to differentiate.
Phosphorylation of Hand1 induced nucleolar to nucleoplasm translocation of Hand1 and commitment of stem cells to differentiate into giant cells.
Clinical researchers may take advantage of the clinical utility of the ASAGC including its ability to differentiate between commitment to abstinence versus commitment to harm reduction.
Epidermal homeostasis involves the intricate regulation and balance between proliferation of basal cells and their commitment to terminally differentiate.
These results demonstrate a specific requirement for Akt1 signalling during the MCE that precedes pre-adipocyte commitment to terminally differentiate.
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