Exact(3)
It is commonly accepted that the commitment point for apoptosis is MOMP.
By ∼22 h after NGF withdrawal, only 50% of the neurons can be rescued by the readdition of NGF and this was defined as the commitment point for NGF withdrawal-induced death.
This time-point represents the transcriptional commitment point for sympathetic neurons undergoing NGF withdrawal-induced apoptosis and induced genes known to be required for NGF withdrawal-induced death, e.g. c-jun, bim, and egln3, are expressed at a high level at this time.
Similar(57)
A detailed understanding of the apoptotic pathway commitment point is crucial for the development of new therapeutic strategies to combat undesirable apoptosis that occurs in certain degenerative diseases and in acute injury, such as ischemia.
Sympathetic neurons are one of the few cell types in which this occurs, making this a useful model for understanding the mitochondrial death commitment point in general.
In budding yeast, Cdc48 is required for passing Start, the cell cycle commitment point in G1, by degrading the G1-cyclin-dependent kinase inhibitor Far1 [14].
Their commitment points to the value attached to examination success.
Importantly, there appears to be a commitment or decision point for these cells that occurs in late RC or early OX phase, and if the commitment has been made, a cell will undergo growth, division and complete the sequential, temporally regulated expression of OX and RB phase genes (Figure 7).
There is a different angle to it when we take high professional commitment as the starting point for a strategy of improving motivation.
However, some could argue the $500 million commitment is merely a selling point for future recruitment.
Thus, MYOGENIN activity constitutes a pivot point for irreversible commitment to terminal differentiation.
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