Previous studies have shown that CD8 T cells exposed to antigen ex vivo for a brief period are committed to undergo several rounds of division in the absence of the continuous presence of antigen [35] [37].
Caspase 3 is a cytosolic enzyme that is activated only in cells committed to undergo apoptosis.
Extensively damaged cells are committed to undergo apoptotic cell death [ 13].
Each Drosophila neuroblast divides asymmetrically to produce a larger daughter cell that retains neuroblast identity, and a smaller daughter cell that is committed to undergo differentiation.
If the cell-specific affinity a decreases below a certain threshold amin, the cell loses the ability to change back to context A, and is committed to undergo further proliferation and differentiation.
When examined in detail, some aspects of the PpiMHCIIa expression pattern further suggest that beyond stem cells, this myosin is associated with cell proliferation, including in progenitors that are already committed to undergo differentiation.
Only after retinoic acid administration, many Smc6-positive spermatogonia were found, showing that the presence of Smc6 indeed marks spermatogonial differentiation and thus the transition after which spermatogonia are irreversibly committed to undergo meiosis and subsequent spermiogenesis.
Cancer stem cells (CSC s are undifferentiated cells that expand their colony through asymmetric cell division, the result of which is two daughter cell population, one being similar to the mother cells, retaining stem cell properties, while the other one is committed to undergo a specified differentiation [ 1].
By providing updated metrics for a new reality, LRN hopes its HOW report will help point the way for companies committed to undergoing the deep work of true transformation.
The conclusion from these studies is that there is dynamic expression of Notch pathway components in embryonic and adult epidermis and that the pathway is primarily active in cells of the IFE and HF that are committed to, or undergoing, terminal differentiation.
