Sentence examples for commit to a specific lineage from inspiring English sources
Second, the treatment was applied in cultures on collagen substratum, under conditions that promote differentiation of mammosphere-derived cells (multipotent progenitors commit to a specific lineage) (Fig. 1b).
It is important to note that AK2 knockdown did not alter the number of hematopoietic progenitors or the latter's ability to proliferate; in fact, AK2 is required when the cells commit to a specific lineage pathway.
However, the necessity for self-renewal must be transient, as the cells are also required to differentiate and commit to a specific lineage.
Such instructive functions by the Rb family during cell fate determination may no longer be required once a cell becomes committed to a specific lineage, and the major function of Rb in committed cells might be to allow proper cell cycle exit and survival; a function that can be bypassed by survival factors or hypoxia.
Cardiac stem cells (CSCs) are present in the adult mammalian heart at different physiological states [6], in that the CSC pool is composed of primitive cells expressing the pluripotent markers and also progenitor cells that have already committed to a specific lineage.
Adult stem cells have a more restricted ability to differentiate, being committed to a specific lineage.
Is it the case that these label-retaining epithelial cells may be pluripotent or multipotent stem cells, giving rise to progeny committed to a specific lineage?
The transplantation of stem cells which are committed to a specific lineage can avoid in vivo teratoma formation which is caused by the rapid growth and uncontrolled spontaneous differentiation of hPSCs [ 8].
How functionally differentiated cells already committed to a specific cell lineage can transdifferentiate into other cell types is a key question in cell biology and regenerative medicine.
