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But the proteins and signals that allow a cell to stay immature or commit to a specific fate are still unknown.
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Ms. Mathis, The Times spokeswoman, confirmed that the newspaper did not commit to a specific date.
But she would not commit to a specific time frame for reviewing a new TransCanada pipeline project.
The question of whether intact somatic cells committed to a specific differentiation fate, can be reprogrammed in vivo by exposing them to a different host microenvironment is a matter of controversy.
It is unclear at what time point an individual cell is committed to a specific cell fate.
Yet, the question of whether genetically unmodified intact cells that are already committed to a specific differentiation default can be reprogrammed to a different fate by ectopic microenvironmental cues, is still a matter of controversy [e.g. 2] [4].
Such instructive functions by the Rb family during cell fate determination may no longer be required once a cell becomes committed to a specific lineage, and the major function of Rb in committed cells might be to allow proper cell cycle exit and survival; a function that can be bypassed by survival factors or hypoxia.
Many B corps are also committed to a specific social mission.
Adult stem cells have a more restricted ability to differentiate, being committed to a specific lineage.
It suggests that progenitor cells committed to a specific tissue type also have hematoblastic potential.
At low concentrations, BMP can keep cells pluripotent, but it cannot encourage cells to commit to a mesoderm fate.
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