Sentence examples for commit a cell from inspiring English sources

However, sustained UPR signaling can eventually commit a cell to apoptosis.

MMP can even commit a cell to die when caspases are not activated.

Therefore, growth history does not commit a cell to a given fate, but is instead context dependent and relative to the growth history of the entire population.

Caspases are the central components of the apoptotic response and a conserved family of enzymes that irreversibly commit a cell to die.

Furthermore, TNF-R is associated with pro-caspases through adapter proteins such as Fas-associated protein with death domains (FADD) and TNF-R-associated death domains (TRADD), resulting in the activation of caspase cascades that can irreversibly commit a cell to apoptosis [ 5].

Because caspase-8 also participates in mitogenic signaling in response to FasL (refer to liver regeneration), it is well possible that this activity has to be eliminated by degrading caspase-8 in a caspase-3-dependent manner in order to fully commit a cell to apoptosis.

In this process, mitochondrial outer membrane permeabilisation or MOMP represents the defining event that irrevocably commits a cell to die.

Together, this spatial and functional regulation of Survivin abolishes its cytoprotective effect toward the apoptotic executors and thus commits a cell to apoptosis.

Permeabilization of the mitochondrial outer membrane is the critical step which irreversibly commits a cell to apoptosis in the intrinsic pathway.

First and foremost the new results challenge the current model in which cyclin D/CDK starts the process of E2F-dependent transcription, which causes the accumulation of cyclin E/CDK and triggers the positive feedback mechanism that commits a cell to dividing.

The growth of a metazoan body relies on a series of highly coordinated cell-fate decisions by stem cells which can undergo self-renewal, reversibly enter a quiescent state, or terminally commit to a cell specification program.