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The lab-scale fermentation results, including the time course data for EPA titer, rate, and yield, are used to determine the very top strains to be scaled up in pilot-scale fermentors under commercially achievable medium and process conditions (Fig. 5d).
After we selected the top candidate strains by micro-fermentation analysis, we needed to further optimize the medium and process conditions (e.g., T, pH, DO, substrate feed) for a given strain to maximize its EPA production and minimize by-product formation (e.g., organic acids), in order to reduce the cost of manufacture (COM) under commercially achievable conditions.
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Further, in contrast to previously published studies of OPT in adult mouse tissues[19], these methods are achievable using commercially-available equipment and software.
If these well-designed commercially-available systems are coupled with the other key socio-technical concepts required for safe and effective EHR implementation and use, and organizations have access to implementable clinical knowledge, we expect that the transformation of the healthcare enterprise that so many have predicted, is achievable using commercially-available, state-of-the-art EHRs.
Obama achieved the achievable.
Set achievable goals, and achieve set goals.
We anticipate that a high-throughput configuration of the current PathogenMip assay will be achievable through use of the commercially available Affymetrix TAG4-array [30], which is based on detection of barcodes through hybridization similar to the process described here.
At higher levels of esterification (53%), pectin has also been shown to match the levels of inhibition achievable to that of the commercially available drug orlistat, 82% inhibition against 88% inhibition for that of orlistat (Kumar & Chauhan, 2010).
Britain's National Grid, the transmission operator for electricity and gas, likes the project, describing it as "Technically feasible...Politically achievable...Commercially viable".
Closing Guantánamo is achievable.
Is it achievable?
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