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The technology is open source with PHP, built on a Zend Framework and coupled to Perforce, which stores everything including code, assets, and metadata such as comments and review status.
Thanks again for your comments and review.
A special thanks to Prof. Gilles Dussault for comments and review made to the final document.
Authors' response: Thank you very much for your detailed comments and review which helped us to focus our editing efforts and improve our arguments.
We thank B. Imanian for primer design and R.B. Moore for sharing unpublished results, Todd Harper for comments and review of this manuscript and Daniel Poland and Jill Mansfield from Professor Coffroth lab, State University of New York at Buffalo, USA for experimental analysis.
Comments and review of paper: SC, DO, EC.
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We thank Drs. Gisela Erf (University of Arkansas) and Douglas Foster (University of Minnesota) for helpful comments and reviewing this manuscript.
Dr. Karen Canfell and Mr. Robert Walker (Cancer Council NSW, Australia) are gratefully acknowledged for comments and reviewing this manuscript.
When the final versions of the manuals were made available to health care providers for comment and review their feedback was generally positive.
David Polly and an anonymous reviewer provided thoughtful comments and reviews of an earlier draft of this manuscript.
GP contributed to data interpretation, provided comments on and reviewed the manuscript critically for important intellectual content and quality.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com