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Regarding negative cost, low potential measures, they would require measures similar to those commented above, because again what is needed is to remove non-economic barriers.
As commented above, the high metabolic cost of proline biosynthesis may be the reason.
As commented above, the data consists of knock-out and hypomorph experiments, with the latter corresponding to essential genes [ 16].
As commented above, different criteria may be used and the best choice may depend on the nature of the problem.
As commented above, the spiking-like oscillations are a consequence of SNIC bifurcation, while Hopf one produces more sinusoidal oscillations.
As commented above, it has become clear the role played by the apoptotic alterations occurring during the development of neoplastic diseases.
As commented above, the improvement factor which we find is close to the additional cost of the simulation and therefore the two algorithms perform rather similarly.
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(See also comment a above).
noap.needman -- not sure about "null" comment above.
Unfortunately, the authors are not addressing comments above.
I really appreciate all the comments above and I strongly support the personal suggestions & experiences mentioned.
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