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The study therefore holds bias for those suitable to commence chemotherapy and our patient cohorts are somewhat heterogeneous, which future prospective validation should seek to address and control for.
Indications to commence chemotherapy were radiological progression (n=17), tumour grade (n=25), progressive symptoms related to increasing tumour burden (rather than hormone secretion) (n=36) or intention of downstaging the disease for surgery (n=4).
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Before commencing chemotherapy, each patient had an incisional tumor biopsy as previously described [1].
Before commencing chemotherapy, each patient had an incisional tumor biopsy as described previously [14].
Each patient had snap-frozen tumor tissue specimens collected prior to commencing chemotherapy.
EDTA clearance was performed prior to commencing chemotherapy.
Acute CINV is observed within 24 hours of commencing chemotherapy and may last for several hours.
Before commencing chemotherapy, each patient participating in one of these trials had an incisional tumor biopsy as described previously [ 9].
Following diagnosis of early breast cancer, women need to make rapid decisions regarding fertility interventions before commencing chemotherapy.
A total of 123 female patients (median age 52 (range 31 78) years) commencing chemotherapy for breast cancer were recruited.
Prior to commencing chemotherapy sperm analysis, hormone (LH, FSH, testosterone) analysis, audiometry and pulmonary function tests were performed.
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