Along with the reprieve come drawbacks — most significantly a larger total debt from the smaller payments.
Yet, along with these benefits come drawbacks [ 5], among them that mtDNA is a single recombinational unit that can present a biased snapshot of evolutionary history when mtDNA data are not balanced by independent evidence from nuclear markers.
Plus, performing classical music in nontraditional spaces often comes with drawbacks like poor acoustics, drunken audiences and the frequent comings and goings of makeshift concert settings, which can hamper the ability of a grassroots music organization to build a following.
But trying to be all things to all people comes with drawbacks.
Nuclear power comes with drawbacks that must be considered along with the benefit of lowering carbon emissions.
"I think transparency in all walks of life is a good thing," Grigorieff says, "but it sometimes comes with drawbacks, and one has to balance these two".
But it also comes with drawbacks for politicians, especially in the post-Citizens United era.
With its anisotropic structure, bone machining occurs as shear/serrated cutting mechanisms at low values of uncut chip thickness while at high values it results in fracture cutting mechanisms which lead to significant tissues damages; hence, utilising conventional tools at high material removal rates comes with drawback on surface damages, situation that needs to be avoided.
With speed and ease of methodology comes the drawback of variable and sometimes ineffective RNAi, especially when using feeding RNAi as opposed to RNAi by injection.
Whilst the number of techniques and predictive assays designed to assess the oxygenation status or the proliferative ability of tumours is rather large, they all come with drawbacks which limit their implementation as routine clinical procedures.
But even when the food was at its best, being the food critic in a mid-size city came with drawbacks I had never imagined.
