Exact(3)
Our objective was to identify potential functional candidates in the CUBN gene by combining the association that was found in Boger et al.[ 8], with these newly available datasets.
Our principal result is that it is possible to substantially improve the prediction of the association of a DNA-binding motif with an annotation term by mapping the annotation from a key species to related species, and combining the association scores for a single motif and term across species.
In complex trait genetics, the two most well-known applications of multi-ethnic GWA studies are meta-analyses, combining the association signals in different populations to increase the power for detecting new risk loci, and fine-mapping, using the divergent genomic structure between different populations for finding the causal genetic variant in a shared risk locus.
Similar(57)
For all infections combined, the association reached statistical significance only for the 2nd quartile in the unadjusted model (RR = 1.17).
When data from the two independent studies were combined, the association of the rs940739A/T polymorphism with knee OA was maintained (adjusted OR = 1.44, 95% CI = 1.16 1.80, p = 0.001).
For men and women combined, the association between BMI and advanced neoplasia was not significant neither in the univariate nor the multivariate analyses (Tables 2 and 3).
When all sets were combined, the association was confirmed (affected family-based controls, RA index cases 64.6% versus controls 58.1%; P = 0.005).
Fixed-effects models weighted by inverse variance [ 56] were applied to combine the association results across studies, yielding a total of 4,586,301 association P values as the input for the MAGENTA analysis.
Furthermore, when these four types of infections were combined, the association was more stable and the magnitude of the dose response relationship was increased, compared with that of the four types of infection taken separately.
For cross-ethnicity mapping, on the other hand, inter-population heterogeneity can be advantageous; cross-ethnicity mapping combines the association signals across multiple different ethnicities, increasing the power for finding new risk loci and identifying causal variants.
When risk estimates from the five studies that adjusted for physical activity were combined, the association between diabetes and bladder cancer was also stronger (RR 1.43) than the overall result including all studies (RR 1.35).
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