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In our study, combining symptoms or BHR with a doctor's diagnosis certainly achieved high specificities.
A considerable number of articles (n = 15, 37%) used heterogeneous definitions by either defining symptoms (n = 7, 17%) or by combining symptoms and healthcare use (n = 8, 20%).
Our objective is to formulate prediction rules for the diagnosis of influenza with the best diagnostic performance, combining symptoms, signs and context among patients with influenza-like illness.
The second analysis was undertaken to allow the effect of individual symptom characteristics such as severity to be investigated and because combining symptoms can mask significant variations [ 10- 13].
Combining symptoms with reports of a doctor's diagnosis of asthma gave slightly higher specificities than the latter alone (table 4), but the sensitivity of each combination was somewhat lower.
Since the development of clinical prediction rules systematically combining symptoms and other information might be a more useful strategy[ 11], the goal of this study is to formulate a prediction rule for influenza in patients presenting with an ILI with the best diagnostic performance in general practice based on the combination of symptoms, signs and contextual information.
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Several input variables produced similar decision trees, and combining symptom scores that were highly correlated allowed us to form composite variables that had greater predictive power.
The GOLD 2011 document proposed a new classification system for COPD combining symptom assessment by COPD assessment test (CAT) or modified Medical Research Council (mMRC) dyspnea scores, and exacerbation risk.
Therefore, the Global Initiative for Chronic Obstructive Lung Disease GOLDD) 2011 document proposed a new classification system for COPD, combining symptom assessment and exacerbation risk including spirometry to identify disease severity [ 1].
Finally, the patients with COPD were categorized into A, B, C, and D combining symptom assessment by COPD assessment test (CAT) or modified Medical Research Council (mMRC) dyspnea scores, and exacerbation risk according to the 2011 GOLD report.
9 17 This has resulted in a number of multidomain PROMs being developed as measures of disease-specific QoL, typically combining symptom questions with more generic questions that relate to overall well-being, energy/vitality, bodily pain and impacts of disease on physical, social and emotional function.
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