Sentence examples for combining site from inspiring English sources
Combining site investigations with sampling analysis, the materials and production process of Jokhang temple wall paintings have been studied.
The most significant use of bispecific antibodies, however, is for T cell redirection, in which one combining site is directed toward a cell surface target on a cancer cell and the other combining site binds CD3E on T cells to redirect those cells to the targeted cancer cell (see below).
Covalent interactions between antibody combining site residues and substrates have been implicated in the catalytic activity of abzymes elicited by design or occurring naturally in autoimmune disease.
Novel strategies that precisely position a key functional residue in the antibody catalyst combining site have therefore emerged, as demonstrated by crystallographic studies.
Whereas antibodies with a bulky residue at position H100c of hypervariable loop H3 adopt different cavity shapes, other antibodies share a common deep combining site.
More significantly, the MD simulations revealed that the Fab complexes of both α-glycopeptide and β-glycopeptide were not stable, with the ligand dissociating from the combining site.
By combining site-directed mutagenesis, in vitro antibody evolution, affinity measurements and X-ray crystallography of Fab fragments, we identified key interactions across the Hu 15C1 TLR4 interface.
The model of the human receptor of cholecystokinin associated to agonist ligand CCK9 was obtained from a synergistic procedure combining site-directed mutagenesis experiments and in silico modeling.
To overcome this we propose combining site-directed immobilization and protein engineering to increase the number of bonds between a specific enzyme surface and a tailor-made support.
In this study we performed fluorescence resonance energy transfer (FRET) microscopy with a library of fluorescent HERG fusion proteins obtained combining site-directed and transposon-based random insertion of GFP variants into multiple sites of HERG.
The combining sites of Fab 2H2 were mostly located at the variable region of the heavy chain genes.
