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This was achieved using a novel approach based upon combining profile hidden Markov models (HMMs), which represent the separate domains characteristic of MHC class I genes.
DELTA-BLAST constructs a PSSM by combining profile information from conserved domains related to a query sequence, and then searches a sequence database with this PSSM.
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Compared to a DCE, respondents evaluate only one profile scenario at a time, which obviates correctly combining profiles.
(iii) What are the advantages of combining profiling for gene-expression with ChIP-Seq compared to gene-expression alone?
Next, a similarity metric between phages, combining profile-profile comparison scores with sequence identities, was developed to provide a finer classification of virion architectures within every Type.
Despite their diversity, they are thus submitted to significant evolutionary constraints which we attempted to reveal by combining profile-profile comparisons with gene context analyses.
However, the combined profile of the handsome young Bulgarian and the reigning French Open champion is now centre stage.
The combined profile of each gene G is the sum of its pipeline-specific profiles.
The resulting combined profile was wavelet-smoothed to generate the final nucleosome positioning profile.
While the overall results were poorer than the results in Table 2, the combined profile always outperformed Rosetta profile.
For each histone variant, coverage profiles from different time points were summed to generate a combined profile.
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