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If this was necessary we describe the development of the new combined variable in the result section.
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To summarise, the Machine Learning framework used in this study comprises of three key steps: Utilising PCA to reduce the number of variables contained in the original dataset to a smaller set of combined variables in the projected dataset while retaining most of the information contained within it.
The scientific literature presents various methodologies for generating a damage scenario for built-up areas impacted by an earthquake (Erdik et al. 2010), each method combines variables in different ways.
While the above analyses informs our understanding of how individual models compare to one another, we were also interested in combining variables in models to better explain variation in productivity.
Such diverse tasks as fuel formulation, clinical trial design and chemical process optimization are solved using experimental designs to combine variables in specific ways, and regression analysis techniques to dissect out the contribution of each variable to the outcome [ 9].
The multivariate models have two important advantages over the gestalt of physicians; they combine variables in a mathematically optimal manner by weighing the importance of each variable based on evidence (derived from the training data), and they provide a standardised tool for decision-making.
In model 2, where the separate HLP variables are excluded from the model to allow for inclusion of combined HLP, the combined variable was forced to remain in the model, but did not reach statistical significance.
It was constructed by a combination of the different individual factors: workers that scored 'abnormal' in at least one item were scored 'abnormal' in the combined variable; workers that scored 'normal' in all items were categorised as 'normal' in the combined variable.
This combined variable was used in all the analyses.
The combined variable was entered in multivariate models and adjusted for the same covariates.
Univariate analyses for the combined variable are given in Table 3.
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